Novartis not too long ago introduced the acquisition of Mariana Oncology, an rising biotech centered on advancing a radioligand therapeutics platform, for as much as $1.75 billion in upfronts and future milestones.
The capstone of its three quick years of operations, this acquisition represents the second largest preclinical M&A deal in historical past, and the most important ever accomplished by Novartis. It additionally represents a shift in radioligand remedy deal exercise: a real platform acquisition, slightly than one centered on a late-stage asset.
Mariana’s acquisition and the extremely thrilling radioligand remedy (RLT) house has been lined extensively elsewhere (right here, right here, right here), however we thought sharing a number of of the important thing people-related themes worthwhile.
This deal reinforces the oft-cited axiom in enterprise investing that discovering and backing nice groups is vital to success, and a giant a part of that’s leveraging deep relationships throughout the ecosystem.
Let’s begin with CEO-Founder Simon Learn, who has now joined that rarefied air of serial entrepreneurs who’ve efficiently had greater than only a fortunate billion greenback singleton; Simon was the CSO at Ra Pharma, which was acquired for $2.5B by UCB Pharma again in October 2019 (right here). We had Simon on our “PeopleFlow” listing instantly following that acquisition, and by the tip of 2019 we have been actively recruiting him. Thankfully for Atlas, he began as an Entrepreneur-in-Residence (EIR) within the spring. In reality, Simon was one among our first “digital EIRs” to begin in the course of the early days of the COVID lockdown. For the preliminary six months or so, Simon labored throughout a number of Atlas firms, together with advising Vigil, Q32, Third Harmonic, and others.
Within the fall of 2020, Simon started working intently with my accomplice Kevin Bitterman and Atlas’ Jernej Godec, who spent the prior yr starting to formulate a thesis round radiopharmaceuticals, an effort termed “Venture Curie”. A vital element of this thesis had turn out to be the assumption that low molecular weight ligands, similar to macrocyclic peptides like these Simon had helped uncover and develop at Ra, can be a key enabler of radioligand pharmacology. Simon was fast to acknowledge the potential alternative on this house and started working to strengthen and refine the nascent technique. To assist the hassle, we additionally introduced on Sandy Mong from BridgeBio to work as an EIR with Simon on the undertaking. The ultimate startup pitch to the partnership was in April 2021, and Venture Curie was seeded on Might 3, 2021 – propitious timing, because it was precisely 3 years to the day that Novartis closed its acquisition of the corporate.
Initially, we partnered with Dan Becker and Christine Borowski of Entry Industries (with whom we’ve finished a number of offers with) on fleshing out the plans for the seed funding, each of whom have been distinctive companions in serving to pull all of it collectively. Particularly, Christine and Jernej have been a useful duo for Simon to lean on, partly as a result of they’d beforehand labored collectively at Appletree. They have been each instrumental within the founding of the corporate and its early plans, particularly in the course of the 18+ months that Curie/Mariana incubated within the Atlas places of work from mid-2021 till February 2022.
In Atlas’ April 2021 seed funding memo, crafted with Simon and Entry, the crew spelled out a lot of the imaginative and prescient for what made Mariana a hit: the vital platform enablement that will set up Mariana as a pacesetter on this rising discipline, in addition to the compelling goal alternative with the preliminary lead program (now referred to as MC-339) in small cell lung most cancers. Nice preliminary goal choice isn’t solely essential for advancing a pipeline, but additionally for early platform improvement.
Shortly after our seed funding, we additional strengthened the broader syndicate by combining forces with our associates at RA Capital, Josh Resnick and Laura Tadvalkar, who have been engaged on a NewCo with the same focus. Notably, CSO Alonso Ricardo, who was an EIR at RA Capital, had beforehand labored alongside Simon Learn at Ra Pharma. And Josh was additionally beforehand a Enterprise Companion at Atlas, and is an effective private buddy with many people at Atlas as properly. It was very very like bringing the band again collectively!
Bernard Lambert, CTO of Mariana, was additionally a key early rent, becoming a member of a couple of yr into the journey from Telix Pharma, a focused radiopharmaceutical participant. Bernard actually has extra years of radiopharm expertise than in all probability anybody on the planet, having labored extensively within the discipline for twenty-four years, and was a key enabler for the know-how. Like most new tech platforms, integrating deep area expertise – together with scars and gray hair from prior studying cycles – is vital to success.
Mariana’s COO/CFO Linda Bain was the ultimate member of the senior management crew to hitch, and helped scale the corporate into its $175M Sequence B elevate final fall, in preparation for a possible path to an IPO. Linda got here to Mariana from Codiak Biosciences, the place she was the CFO for seven years, and helped lead their 2020 IPO. Extensively thought to be an exceptionally gifted chief, we tried exhausting for a number of years to recruit Linda. Because of the concerted effort of your complete Atlas crew, and particularly Andrea DiMella (our head of expertise), we have been capable of assist her land at Mariana.
One of many many recruitment actions that helped: Linda ran the Attain The Seaside relay with us in Sept 2022 and was caught in a van with me for 30+ hours. She could have mentioned sure to becoming a member of an Atlas startup simply to flee future time within the vans! Funnily sufficient, Simon additionally ran RTB with us, again in 2021. Working is the brand new golf, as we prefer to say. This highlights one other axiom within the enterprise enterprise: discovering distinctive methods to construct deeper neighborhood pays dividends over the long term.
As for all rising biotechs, BD is an ever-present exercise – speaking to companions and conserving them updated. That mentioned, the BD course of that culminated with this acquisition actually kicked off in earnest final fall because the story got here collectively for the Sequence B, and we had line of sight for MC-339 coming into the clinic. At our “Atlas Enterprise Retreat” in November 2023, interactions between Linda Bain and Shiva Malek, head of oncology analysis for Novartis, have been key in organising the BD dynamic in early 2024. The RLT house couldn’t have been hotter, with an unimaginable wave of M&A taking place in parallel with Mariana’s discussions: RayzeBio acquired by BMS, Level by Lilly, and extra not too long ago Fusion by AstraZeneca.
Whereas many events have been , Novartis stood out for its conviction round RLT (together with its current marketed portfolio of Lutathera and Pluvicto) and our confidence of their capacity to hold ahead the crew and platform into the clinic. In late January, following a name we had with Novartis’ Ronny Gal and Susanne Kreutz about a number of ongoing dialogues within the portfolio, Novartis expressed their curiosity in transferring ahead with an acquisition to each Simon and Atlas. Our companions at Centerview helped finalize the deal – additional strengthening their unimaginable market share within the >$1B deal class: they’ve finished at the very least 55 M&A offers higher than $1B since 2019, greater than the following 9 advisors mixed.
As we shut this chapter of what we hope is a for much longer Mariana Oncology story, we’d prefer to thank your complete CurieTx/Mariana crew that helped information this over the previous 3-4 years – and all these within the broader ecosystem that helped with its success.
It’s at all times all about relationships and other people – and, in fact, the power these interactions emit!
